| Bioactivity | Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP). Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation[1]. |
| Invitro | Sanggenon G (14.4 μM, 24 h) 增强 caspase-8、-3 和 -9 的切割，从 XIAP 中置换 caspase-9 并使 Molt3/XIAP 细胞对 Etoposide (HY-13629) 诱导的细胞凋亡敏感[1]。Sanggenon G 不仅使过表达 XIAP 的白血病细胞系 Molt3/XIAP 对依托泊苷 (HY-13629) 治疗敏感，而且使内源性表达高水平 XIAP 的不同神经母细胞瘤细胞系敏感[1]。 |
| Name | Sanggenon G |
| CAS | 85698-31-3 |
| Formula | C40H38O11 |
| Molar Mass | 694.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Seiter MA, et al. Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP). FEBS Open Bio. 2014 Jul 5;4:659-71. |
Sanggenon G
CAS: 85698-31-3 F: C40H38O11 W: 694.72
Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP). Sanggenon G bind
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