| Bioactivity | Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells[1]. |
| Invitro | Salviolone（5-60 μM；72 小时）降低 A375 和 MeWo 黑色素瘤细胞系的细胞活力，EC50 值分别为 17 μM 和 22 μM。Salviolone 不影响正常黑色素细胞的生长[1]。Salviolone（20 μM；48-72 小时）强烈降低 A375 细胞中的 pRb、pCdk2 和细胞周期蛋白 A2、Tyr705-STAT3 磷酸化表达水平。 Salviolone 还强烈增加 P21 和 P53 蛋白表达水平。Salviolone 诱导 ERK1/2 和 Akt 磷酸化的持续激活[1]。Salviolone (10-20 μM) 抑制 A375 黑色素瘤细胞系中的 MMP2 明胶酶活性[1]。 Cell Viability Assay[1] Cell Line: |
| Name | Salviolone |
| CAS | 119400-86-1 |
| Formula | C18H20O2 |
| Molar Mass | 268.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Valentina Zanrè, et al. Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 Phosphorylation. Int J Mol Sci. 2022 Jan 20;23(3):1121. |