| Bioactivity | Salvinorin A (Divinorin A) propionate is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A propionate is a non-nitrogenous neoclerodane isolated from Salvia divinorum[1]. |
| Invitro | Salvinorin A（0.01-10 pM；预处理30分钟；24小时）在巨噬细胞中经过24小时的暴露后不影响膜功能[1]。Salvinorin A（0.01-10 pM；预处理30分钟；18小时）在 LPS 刺激前显著降低 LPS 诱导的亚硝酸盐水平，且这种降低呈现浓度依赖性，其中 Salvinorin A 的抑制效应的 IC50（95% 置信区间）为 6.5×10−13M[1]。Salvinorin A（0.01-10 pM；预处理30分钟；18小时）在 LPS 刺激前孵育30分钟，可以浓度依赖性地减少 LPS 诱导的 iNOS 超表达，但对 COX-2 的超表达没有影响，在10 pM浓度时达到统计学显著性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Salvinorin A propionate 相关抗体: |
| CAS | 689295-71-4 |
| Formula | C24H30O8 |
| Molar Mass | 446.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Butelman ER, et al. Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Front Pharmacol. 2015 Sep 8; 6:190., et al. [2]. John TF, et al. The antinociceptive effect of salvinorin A in mice.Eur J Pharmacol. 2006 Sep 18;545(2-3):129-33. Epub 2006 Jul 4. |
Salvinorin A propionate
CAS: 689295-71-4 F: C24H30O8 W: 446.49
Salvinorin A (Divinorin A) propionate is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) ag
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