| Bioactivity | Sal003 is a potent, specific and cell-permeable inhibitor of the eukaryotic translation initiation factor 2α (eIF2α) phosphatase. Sal003 is a derivative of salubrinal[1]. | ||||||||||||
| Invitro | Sal003 (20 μM; 1-12 hours) sharply increases eIF2α phosphorylation in mouse embryonic fibroblasts (MEFs)[2].Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation by Sal003 (10 μM; 1 hour) enhances subtilase cytotoxin (SubAB)-induced apoptotic signaling[1].Sal003 promotes eIF2α phosphorylation leads to impairment of synaptic plasticity and memory[1]. Apoptosis Analysis[2] Cell Line: | ||||||||||||
| Name | Sal003 | ||||||||||||
| CAS | 1164470-53-4 | ||||||||||||
| Formula | C18H15Cl4N3OS | ||||||||||||
| Molar Mass | 463.21 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Sal003
CAS: 1164470-53-4 F: C18H15Cl4N3OS W: 463.21
Sal003 is a potent, specific and cell-permeable inhibitor of the eukaryotic translation initiation factor 2α (eIF2α) p
Data collection：peptidedb@qq.com
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