| Bioactivity | Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression[1]. |
| Invitro | Safrazine (0.1-0.5 μM; 0-80 min) strengthenes the inhibitory potency by preincubation in a time-dependent manner[1]. |
| In Vivo | Safrazine (oral; 3, 10, 30 mg/kg) causes the increases contents of monoamine lasted for at least 24 h[1].Safrazine strongly inhibits both 5-HT and PEA deaminations, but shows no selectivity toward the substrate used[1]. Animal Model: |
| Name | Safrazine |
| CAS | 33419-68-0 |
| Formula | C11H16N2O2 |
| Molar Mass | 208.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. T Yokoyama, et al. Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain. J Pharm Pharmacol. 1989 Jan;41(1):32-6. |