| Bioactivity | Sabizabulin hydrochloride is a potent orally bioavailable microtubule inhibitor with activity that interacts with the colchicine binding site. Sabizabulin hydrochloride demonstrated significant inhibition of melanoma tumor growth with an average IC50 of 5.2 nM in melanoma and prostate cancer cell lines. Pharmacological screening of Sabizabulin hydrochloride shows it has a low risk of potential side effects[1]. |
| CAS | 2635953-17-0 |
| Formula | C21H20ClN3O4 |
| Molar Mass | 413.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1 H-Indol-3-yl)-1 H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin |
Sabizabulin hydrochloride
CAS: 2635953-17-0 F: C21H20ClN3O4 W: 413.85
Sabizabulin hydrochloride is a potent orally bioavailable microtubule inhibitor with activity that interacts with the co
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