| Bioactivity | SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[1][2]. | ||||||||||||
| Invitro | SZL P1-41 (5-20μM; 24 hours) induces endogenous p27 protein expression in PC3 cells and also induced expression of p21, another Skp2 substrate[1]. | ||||||||||||
| Name | SZL P1-41 | ||||||||||||
| CAS | 222716-34-9 | ||||||||||||
| Formula | C24H24N2O3S | ||||||||||||
| Molar Mass | 420.52 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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SZL P1-41
CAS: 222716-34-9 F: C24H24N2O3S W: 420.52
SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF compl
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