| Bioactivity | SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC50 of 1.6 μM. SYM2206 blocks Nav1.6-mediated persistent currents[1][2]. | ||||||||||||
| Name | SYM2206 | ||||||||||||
| CAS | 173952-44-8 | ||||||||||||
| Formula | C20H22N4O3 | ||||||||||||
| Molar Mass | 366.41 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Bleakman D, et, al. Kainate receptor agonists, antagonists and allosteric modulators. Curr Pharm Des. 2002;8(10):873-85. [2]. Welch NC, et al. Traditional AMPA receptor antagonists partially block Na v1.6-mediated persistent current. Neuropharmacology. 2008 Dec;55(7):1165-71. |