| Bioactivity | SYD5115 is an orally available TSH-R antagonist,[1][2]. |
| Invitro | SYD5115 (0.1 nM-10 μM) 可阻断 M22 诱导的 cAMP 产生，在大鼠 FRTL5 和 HEK293-hTSHR 细胞中的 IC50s 分别为 22 nM[1]。Note: M22 是刺激型的人单克隆 TSH 受体 (TSHR) 的自身抗体，另一种自身抗体是 K1-70（阻断型）[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SYD5115 相关抗体: |
| Formula | C22H32F2N4O3 |
| Molar Mass | 438.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Karstens WFJ, et al. Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist. Bioorg Med Chem. 2023 Apr 15;84:117258. [2]. Furmaniak J, et al. In vivo effects of a human thyroid-stimulating monoclonal autoantibody (M22) and a human thyroid-blocking autoantibody (K1-70). Auto Immun Highlights. 2011 Sep 14;3(1):19-25. |