| Bioactivity | SWELYYPLRANL-NH2 is an E-cadherin and N-cadherin antagonist. SWELYYPLRANL-NH2 inhibits phage clone binding to E- or N-cad/Fc chimeric protein (IC50: 0.7 and 0.09 μM respectively). SWELYYPLRANL-NH2 inhibits cell aggregation. SWELYYPLRANL-NH2 can be used to promote drug delivery through epithelial and endothelial permeability barriers[1]. |
| Target | E-cadherin, N-cadherin |
| Name | SWELYYPLRANL-NH2 |
| Sequence | Ser-Trp-Glu-Leu-Tyr-Tyr-Pro-Leu-Arg-Ala-Asn-Leu-NH2 |
| Shortening | SWELYYPLRANL-NH2 |
| Formula | C73H106N18O18 |
| Molar Mass | 1523.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Devemy E, et al. Identification of a novel dual E- and N-cadherin antagonist. Peptides. 2009 Aug;30(8):1539-47. |