| Bioactivity | SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH)-P inhibitor with IC50s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH[1]. | ||||||||||||
| Target | IC50: 4 μM (human sEH-P) and 2.8 μM (rat sEH-P) | ||||||||||||
| Name | SWE101 | ||||||||||||
| CAS | 2376322-12-0 | ||||||||||||
| Formula | C19H15Cl2NO3 | ||||||||||||
| Molar Mass | 376.23 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kramer JS, et al. Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain. J Med Chem. 2019 Aug 22. |