| Bioactivity | SW203668 is a benzothiazole compound, shows anti-tumor activity against lung cancer cell lines (IC50=0.022-0.116 μM)[1]. |
| Invitro | SW203668 (0.1, 0.3, 1, 3，和 10 μM) 有 2 个苯并噻唑对映体，(+)-SW203668 比 (-)-SW203668 更能与 p37/p30 结合[1]。SW203668 (1 nM-10 μM; 2 d) 抑制 H2122 细胞生长，IC50 分别为 0.029 μM ((+)-SW203668) 和 0.007 μM ((-)-SW203668)[1]。 |
| In Vivo | SW203668 (25 mg/kg; 腹腔注射; 单次剂量) 在小鼠血浆中半衰期为 8 小时，(6mg /kg, 20mg /kg; 腹腔注射; 每天1次，持续 15 天) 对 CD-1 小鼠低毒[1]。SW203668 (20 mg/kg; 腹腔注射; 每天 1 次，持续 14 天) 能够保存皮脂细胞，并显著增加小鼠的皮脂细胞数量[1]。SW203668 (20 mg/kg; 腹腔注射; 每天1次，持续 14 天) 对含有H2122细胞来源的肿瘤异种移植的免疫缺陷型非肥胖糖尿病严重联合免疫缺陷(NOD-SCID)小鼠显示出抗肿瘤效果[1]。 |
| Name | SW203668 |
| CAS | 1673556-40-5 |
| Formula | C22H19N3O2S |
| Molar Mass | 389.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Theodoropoulos PC, et al. Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nat Chem Biol. 2016 Apr;12(4):218-25. |