| Bioactivity | SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus. | ||||||
| Invitro | SV40 large tumor-antigen (T-ag) nuclear import is enhanced by the protein kinase CK2 (CK2) site (Ser111Ser112) flanking the nuclear localization sequence (NLS)[1]. T-ag NLS can enhance nuclear import, despite the fact that PK-C has been shown to inhibit nuclear import of proteins such as lamin B2[2]. | ||||||
| Name | SV40 large T antigen NLS | ||||||
| Sequence | Cys-Gly-Gly-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Glu-Asp | ||||||
| Shortening | CGGGPKKKRKVED | ||||||
| Formula | C58H104N20O18S | ||||||
| Molar Mass | 1401.70 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |