| Bioactivity | STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis[1][2]. | ||||||||||||
| Invitro | STL127705 (Compound L) (0-100 µM) inhibits binding of Ku70/80 to a DNA substrate and inhibits Ku-dependent activation of the DNA-PKCS kinase[1].antiproliferative activity (0-100 µM; 6h) decreases the expression of DNA-PKCS auto-phosphorylation in SF-767 cells[1].STL127705 (0-40 µM; 6h) shows antiproliferative activity in a dose dependent manner[1].TL127705 (1 µM; 48 h) significantly promotes apoptotic when combination with gemcitabine[2]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | STL127705 | ||||||||||||
| CAS | 1326852-06-5 | ||||||||||||
| Formula | C22H20FN5O4 | ||||||||||||
| Molar Mass | 437.42 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
STL127705
CAS: 1326852-06-5 F: C22H20FN5O4 W: 437.42
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.