STL1267_product_DataBase

CAS: 1429024-58-7 F: C17H11ClN4O W: 322.75

STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1[1].

Target

Ki: 0.16 µM (REV-ERBα)

Invitro

STL1267 (5 µM; 24 h) 在 HepG2 细胞中降低 BMAL1 的表达并增加 Mtnd1、Mtco1、Vicad、Lcad、Scad、Lkb1、Sirt1、Nampt、Ppargc1a 的基因表达[1]。 Cell Viability Assay[1] Cell Line:

In Vivo

STL1267 (50 mg/kg; i.p.; once) 在小鼠体内有效抑制 BMAL1 的表达[1]。 Animal Model:

Name

STL1267

CAS

1429024-58-7

Formula

C17H11ClN4O

Molar Mass

322.75

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Murray MH, et al. Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun. 2022 Nov 21;13(1):7131.

PeptideDB

STL1267

CAS: 1429024-58-7 F: C17H11ClN4O W: 322.75