| Bioactivity | STL001 is potent and selective FOXM1 inhibitor. STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation. STL001 sensitizes human cancers to a broad-spectrum of cancer therapies[1]. |
| Invitro | STL001 (1-10 μM; 24 h) 导致细胞 FOXM1 蛋白水平剂量依赖性降低[1]。STL001 (5 μM; 24 h) 诱导核 FOXM1 易位至细胞质并促进其自噬降解[1]。U2OS-C3-luc cells5 μM24 hResulted in reduced FOXM1 levels with increased expression of autophagy marker protein LC3. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> STL001 相关抗体: Western Blot Analysis[1] Cell Line: |
| Formula | C27H23N7O4 |
| Molar Mass | 509.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sanjeev Raghuwanshi, et al. Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies. Cell Death Discov. 2024 May 2;10(1):211. |