| Bioactivity | STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC50 of 7 nM[1]. |
| Target | IC50: 7 nM (STK33). |
| Invitro | STK33-IN-1 (compound 1) is 2-fold selective for Aurora-B (AurB) versus STK33. STK33-IN-1 (compound 1) has proven unsuccessful in selectively killing KRAS-dependent cancer cell lines[1]. |
| Name | STK33-IN-1 |
| CAS | 1404437-49-5 |
| Formula | C24H27N7O2 |
| Molar Mass | 445.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Michel Weïwer, et al. A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. |