| Bioactivity | STING agonist-30 is a potent STING agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[1]. |
| Invitro | STING agonist-30 (compound 23; 20 μM; 5 h) 增加野生型 HT1080 细胞中的 TBK1 磷酸化，但不增加 HT1080 STING-KO 细胞中的 TBK1 磷酸化[1]。STING agonist-30 (20 μM; 8 h) 增强干扰素 β (IFNβ) 和 TNF-α 的表达[1]。STING agonist-30 (0-20 μM; 5 h) 以剂量依赖性方式激活小鼠和人类 STING[1]。 Western Blot Analysis[1] Cell Line: |
| Name | STING agonist-30 |
| Formula | C15H16N4O8 |
| Molar Mass | 380.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zang R, et, al. Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist. Eur J Med Chem. 2023 Mar 15;250:115184. |