| Bioactivity | STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1]. |
| Target | EC50: 185 nM (STING) |
| Invitro | STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1].STING agonist-12 is not active at mouse STING[1]. |
| In Vivo | STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1]. Animal Model: |
| Name | STING agonist-12 |
| CAS | 2259624-71-8 |
| Formula | C25H19ClF4N2O2 |
| Molar Mass | 490.88 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Pryde DC, et al. The discovery of potent small molecule activators of human STING. Eur J Med Chem. 2021 Jan 1;209:112869. |