| Bioactivity | STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC50 value of 0.121 μM in human and an IC50 value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated STING signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of STING-associated inflammatory and autoimmune diseases[1]. |
| Invitro | STING-IN-8 (0.1, 0.3, 1, 3 μM, 5 h) 抑制人和鼠细胞中 MSA-2 (10 μM) 或 2’, 3’ -cGAMP (10 μM) 诱导的 p-TBK1 和 p-IRF3 上调表达[1]。STING-IN-8 在 THP1-Dual 和 RAW-Lucia 细胞系中 CC50 为 30 μM 时显示出可忽略的细胞毒性[1]。STING-IN-8 (0.3, 1, 3 μM 和 0.1, 1, 3 μM, 9 h) 在人和小鼠免疫细胞中有效抑制 STING 下游免疫炎症细胞因子[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> STING-IN-8 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | STING-IN-8在小鼠体内的药动学参数[1]药代动力学分析[1]Administration |
| Formula | C18H14F3N3O5S2 |
| Molar Mass | 473.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jin Z, et al. Design, synthesis, and evaluation of thiazolecarboxamide derivatives as stimulator of interferon gene inhibitors[J]. Mol Divers. 2024 Apr 29, 1573-501X |