| Bioactivity | STING-IN-3 is an inhibitor of stimulator of interferon genes (STING). STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING[1]. | ||||||||||||
| Target | STING | ||||||||||||
| Invitro | STING-IN-3 (0.02-2 μM) inhibits hsSTING and mmSTING, mediated IFNβ reporter activity in HEK293 cells[1]. | ||||||||||||
| Name | STING-IN-3 | ||||||||||||
| CAS | 2244881-69-2 | ||||||||||||
| Formula | C17H20N2O4 | ||||||||||||
| Molar Mass | 316.35 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Haag SM, et, al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. |
STING-IN-3
CAS: 2244881-69-2 F: C17H20N2O4 W: 316.35
STING-IN-3 is an inhibitor of stimulator of interferon genes (STING). STING-IN-3 efficiently inhibits both hsSTING and m
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