| Bioactivity | STEP-IN-1 (Compound 14b) is a potent and selective STEP inhibitor with an IC50 of 5.27 μM. STEP-IN-1 has a neuroprotective effect, which can protect nerve cells from glutamate-induced toxicity, reduce cellular ROS accumulation, and inhibit apoptosis. STEP-IN-1 can be used in the study of neurodegenerative diseases[1]. |
| Formula | C21H10ClNO7 |
| Molar Mass | 423.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jiang C, et al. Design and synthesis of novel benzoic acid derivatives as striatal-enriched protein tyrosine phosphatase (STEP) inhibitors with neuroprotective properties. Eur J Med Chem. 2025 Feb 5;283:117135. |