| Bioactivity | STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites and significantly reduces the expression of STAT5B protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance[1]. |
| Invitro | STAT5-IN-3 (Compound 14a) (100 nM-10 μM; 48 h) 能抑制髓系白血病细胞 (KU812、K562、KCL-22、MV-4-11 和 MOLM-13) 的活性，EC50 值分别 0.6 μM、0.8 μM、0.5 μM、0.3 μM 和 0.3 μM，而对正常细胞 (HS27A 和 MSC) 的毒性较低，其 EC50 值均 > 10 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> STAT5-IN-3 相关抗体: |
| Formula | C25H27N5O |
| Molar Mass | 413.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Polomski M, et al. Novel antileukemic compound with sub-micromolar potency against STAT5 addicted myeloid leukemia cells. Eur J Med Chem. 2025 Feb 15;284:117211. |