STAT3 degrader-2_product_DataBase

Bioactivity	STAT3 degrader-2 is a PROTAC-based degrader of STAT3. STAT3 degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases[1].
Invitro	STAT3 degrader-2 (Compound 92) (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM; 3 h) 降低急性白血病 Molm-16 细胞中的总 STAT3 蛋白水平[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	STAT3 degrader-2 (Compound 92) (i.v.; 50 mg/kg; 6 h, 24 h, 48 h) 降低急性白血病 Molm-16 肿瘤和 SU-DHL-1 中总 STAT3 蛋白和磷酸化 STAT3 (Y705) 蛋白的水平小鼠肿瘤[1]。STAT3 degrader-2 (i.v.; 25, 50 mg/kg; qw) 对小鼠的 Molm-16 异种移植肿瘤显示出抗肿瘤活性[1]。 Animal Model:
Name	STAT3 degrader-2
CAS	2497583-03-4
Formula	C59H62N9O13P
Molar Mass	1136.15
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Shaomeng Wang, et al. Small molecule degraders of stat3. Patent. WO2020198435A1.

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