| Bioactivity | STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research[1]. | ||||||||||||
| Invitro | STAT3-IN-3 has no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2[1]. STAT3-IN-3 inhibits the growth of MDA-MB-231, HCT-116, HepG2, and MCF-7 cells with IC50s of 1.43 μM, 1.89 μM, 2.88 μM, and 3.33 μM, respectively[1].STAT3-IN-3 down-regulates the expression of STAT3 target genes Bcl-2 and Cyclin D1[1]. STAT3-IN-3 inhibits STAT3 tyrosine phosphorylation and serine phosphorylation[1].STAT3-IN-3 inhibits STAT3 DNA-binding activity[1].STAT3-IN-3 (1-4 μM; 24 hours) increases ROS production and remarkably reduces the mitochondrial membrane potential to induce mitochondrial apoptotic pathway[1].STAT3-IN-3 (1-4 μM; 24 hours) can induce the cleavage of caspase-9, caspase-3 and PARP[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | STAT3-IN-3 | ||||||||||||
| CAS | 2361304-26-7 | ||||||||||||
| Formula | C27H26BrN3O6S | ||||||||||||
| Molar Mass | 600.48 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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STAT3-IN-3
CAS: 2361304-26-7 F: C27H26BrN3O6S W: 600.48
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-
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