Bioactivity | STAT3-IN-24, cell-permeable (PpYLKTK-mts) is a STAT3 peptide inhibitor. STAT3-IN-24, cell-permeable inhibits recruitment of STAT3 to Jak2 and phosphorylation of Y705, thus preventing the dimerization and the nuclear translocation of STAT3[1]. |
Name | STAT3-IN-24, cell-permeable |
CAS | 400628-16-2 |
Sequence | Pro-{Tyr(PO3H2)}-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro |
Shortening | P-{Tyr(PO3H2)}-LKTKAAVLLPVLLAAP |
Formula | C92H157N20O24P |
Molar Mass | 1958.32 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Buettner C, et al. Critical role of STAT3 in leptin's metabolic actions. Cell Metab. 2006 Jul;4(1):49-60. |