STAT3-IN-14_product_DataBase

Bioactivity	STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3[1].
Target	IC50: 0.42 μM (MDA-MB-231); 0.50 μM (MCF7); 0.13 μM (A549)
Invitro	STAT3-IN-14 (Compound 1) shows inhibitory activity against phosphor-STAT3. STAT3-IN-14 (Compound 1) reduces the phosphorylation inhibitory activity against MDA-MB-231 cells (JAK/STAT pathway constitutively active) in does dependent manner, but no inhibitory activities against JAK kinases.STAT3-IN-14 (Compound 1) has growth inhibitory activity with with IC50 values of 0.42 μM, 0.50 μM and 0.13 μM in MDA-MB-231, MCF7 and A549cells, respectively[1]. Western Blot Analysis[1] Cell Line:
Name	STAT3-IN-14
CAS	123297-90-5
Formula	C14H10O5
Molar Mass	258.23
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Teruyuki Tahara, et al. STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae. Bioorg Med Chem. 2020 Mar 15;28(6):115347.

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