| Bioactivity | STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 µM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis[1]. |
| Invitro | STAT3-IN-10 (A11) (48 h) shows IC50 values of 0.67, 0.77, 1.24 µM against MDA-MB-231, MDA-MB-468, HepG2 cells, respectively[1].STAT3-IN-10 (A11) directly binds to the STAT3 SH2 domain [1].STAT3-IN-10 (A11) (0-3 μM, 24 h) inhibits the phosphorylation of STAT3 and its downstream target proteins and has a good selectivity against the tumor suppressor STAT1 [1].STAT3-IN-10 (A11) (0-4 μM, 24 h) induces apoptosis in cancer cells[1].STAT3-IN-10 (A11) (0-4 μM, 24 h) dose-dependently causes a significant S phase arrest in MDA-MB-231 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | STAT3-IN-10 |
| CAS | 2499491-04-0 |
| Formula | C17H13NO5 |
| Molar Mass | 311.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
STAT3-IN-10
CAS: 2499491-04-0 F: C17H13NO5 W: 311.29
STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 µM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces
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