| Bioactivity | ST2-IN-1 (compound 31) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 7 μM in AlphaLISA assay, and 7.19 μM in HEK-Blue assay. ST2-IN-1 effectively attenuats the ST2/IL-33 signaling in human mast cells[1]. |
| Formula | C27H33N5O2 |
| Molar Mass | 459.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xinrui Yuan, et al. Studies of Structure–Activity Relationship of 2-(Pyrrolidin-1ylmethyl)-1H-pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation. ACS Med. Chem. Lett. October 18, 2024. |