| Bioactivity | ST-CY14 is an inhibitor for Nur77-PPARγ interaction with an EC50 of 3.15 μM, that binds to Nur77 (Kd=32 nM), blocks Nur77 from being ubiquitinated and degraded by PPARγ, reduces fatty acid uptake and mitochondrial respiration, and inhibits the transcription of CD36 and FABP4. ST-CY14 inhibits the proliferation and migration of cancer cell MCF7 and MDA-MB-231. ST-CY14 inhibits tumor growth and bone metastasis in mouse models[1]. |
| Sequence | Cys-Glu-Gly-Cys-Lys-Gly-Phe-{S5}-Arg-Arg-Thr-{S5}-Arg-Tyr-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2 |
| Shortening | CEGCKGF-{S5}-RRT-{S5}-RYYGRKKRRQRRR-NH2 |
| Formula | C139H237N57O31S2 |
| Molar Mass | 3266.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bian H, et al., In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPARγ Interaction and Its Anti-Breast-Cancer Efficacy. Adv Sci (Weinh). 2024 Jul;11(26):e2308435. |