| Bioactivity | ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2]. |
| Invitro | ST-1006 (10 μM) 是一种有效的嗜碱性粒细胞迁移诱导剂，可诱导嗜碱性粒细胞迁移[2]。ST-1006 (0-100 μM) 抑制 FceRI 介导的嗜碱性粒细胞激活并降低 FceRI 激活的嗜碱性粒细胞的 CD63 和 CD203c 表达水平[2]。 |
| In Vivo | ST-1006 (1-100 mg/kg；s.c.；雄性 CD-1 小鼠) 具有抗炎作用和止痒作用[1]。 Animal Model: |
| Name | ST-1006 |
| CAS | 1196994-11-2 |
| Formula | C16H20Cl2N6 |
| Molar Mass | 367.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397. [2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73. |