| Bioactivity | SSR182289 (SSR182289A free base) is a selective and potent orally active thrombin inhibitor. SSR182289 competitively and selectivity inhibits human thrombin (Ki=0.031 μM). SSR182289 demonstrates anticoagulant activity in vitro (thrombin time EC100=96 nM) and inhibits tissue factor-induced thrombin generation (IC50=0.15 μM) in human plasma. SSR182289 inhibited thrombin-induced aggregation of human platelets (IC50=32 nM), but has no effect on aggregation induced by other platelet agonists [1][2]. |
| CAS | 363151-21-7 |
| Formula | C30H33F2N5O4S |
| Molar Mass | 597.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jean-Michel Altenburger, et al. SSR182289A, a selective and potent orally active thrombin inhibitor. Bioorg Med Chem. 2004 Apr 1;12(7):1713-30. [2]. Jean-Michel Altenburger, et al. SSR182289A, a selective and potent orally active thrombin inhibitor. Bioorg Med Chem. 2004 Apr 1;12(7):1713-30. |
SSR182289
CAS: 363151-21-7 F: C30H33F2N5O4S W: 597.68
SSR182289 (SSR182289A free base) is a selective and potent orally active thrombin inhibitor. SSR182289 competitively and
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