| Bioactivity | SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells[1]. | ||||||||||||
| Invitro | SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | SSE15206 | ||||||||||||
| CAS | 1370046-40-4 | ||||||||||||
| Formula | C19H21N3O3S | ||||||||||||
| Molar Mass | 371.45 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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SSE15206
CAS: 1370046-40-4 F: C19H21N3O3S W: 371.45
SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance.
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