| Bioactivity | SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1]. |
| Target | SIRT1 |
| In Vivo | SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice[1].SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1].SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1]. Animal Model: |
| Name | SRT3657 |
| CAS | 1383551-17-4 |
| Formula | C40H54N8O6S |
| Molar Mass | 774.97 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gräff J, et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci. 2013 May 22;33(21):8951-60. |