| Bioactivity | SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM[1]. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels[2]. | ||||||||||||
| Invitro | SRT 2183 (1-10 μM; 24-72 hours) inhibits the growth of Reh and Nalm-6 cells in a time- and dose-dependent manner[2]. SRT 2183 (5-10 μM in Reh cells; 10 μM in Ly3 cells; 24 hours) induces expression of DNA-damage response genes associated with accumulation of phospho-H2A.X levels[2]. SRT2183 inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival[3]. Cell Proliferation Assay[2] Cell Line: | ||||||||||||
| Name | SRT 2183 | ||||||||||||
| CAS | 1001908-89-9 | ||||||||||||
| Formula | C27H24N4O2S | ||||||||||||
| Molar Mass | 468.57 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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SRT 2183
CAS: 1001908-89-9 F: C27H24N4O2S W: 468.57
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and
Data collection：peptidedb@qq.com
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