SRPIN803_product_DataBase

Bioactivity	SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration[1][2][3].
Invitro	SRPIN803 抑制 SRPK1 对 LBRNt (62-92) 的活性，IC50 值为 7.5 μM，而 c(RGDyK)-conjugated 化合物完全消除其抑制活性[2]。SRPIN803 对 Hcc827，PC3 和 U87 具有轻微的细胞抑制活性 (GI50=80-98 μM)[2]。
In Vivo	SRPIN803 (眼膏局部给药) 显着抑制年龄相关性黄斑变性小鼠模型中的脉络膜新生血管[3]。SRPIN803 (100 μM; 72 h) 抑制斑马鱼血管生成[2]。SRPIN803 (4.6 nL of 10 μM; 显微注射；72 h) 阻断斑马鱼单细胞期胚胎发育中的血管生成[2]。
Name	SRPIN803
CAS	380572-02-1
Formula	C14H9F3N4O3S
Molar Mass	370.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Leonidis G, et, al. Synthesis and Biological Evaluation of a c(RGDyK) Peptide Conjugate of SRPIN803. ACS Omega. 2021 Oct 14;6(42):28379-28393. [2]. Vedove AD, et, al. A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur J Med Chem. 2020 Jun 1;195:112267. [3]. Morooka S, et, al. Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.

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