| Bioactivity | SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity[1][2]. | ||||||||||||
| In Vivo | SRI 6409-94 causes virgin female outbred syrian golden hamciasters to produce deformed offspring, in a dose-dependent manner[1].SRI 6409-94 leads to reductions in mean fetal body weight and in the numbers of ossified skeletal districts, significantly[1]. | ||||||||||||
| Name | SRI 6409-94 | ||||||||||||
| CAS | 127697-58-9 | ||||||||||||
| Formula | C24H29NO3 | ||||||||||||
| Molar Mass | 379.49 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Willhite CC, et al. Structure-activity relationships of retinoids in developmental toxicology. IV. Planar Cisoid conformational restriction. Toxicol Appl Pharmacol. 1990 Apr;103(2):324-44. [2]. Willhite CC, et al. Structure-affinity relationships of retinoids with embryonic cellular retinoic acid-binding protein. Toxicol Appl Pharmacol. 1992 Jan;112(1):144-53. |
SRI 6409-94
CAS: 127697-58-9 F: C24H29NO3 W: 379.49
SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study
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