| Bioactivity | SRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC50 of 1.44 µM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression[1]. |
| Target | IC50: 1.44 µM (SRD5A1) |
| Invitro | SRD5A1-IN-1 (Compound 4) (0.5-2.5 μM; 24 h) 降低 SRD5A1 蛋白表达[1]。SRD5A1-IN-1 (0-2.5 μM; 12 h) 通过影响 SRD5A1 蛋白表达水平和 SRD5A1 酶活性的双重作用调节 SRD5A1[1]。 Western Blot Analysis[1] Cell Line: |
| Name | SRD5A1-IN-1 |
| Formula | C17H11F6NO3 |
| Molar Mass | 391.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lin A C K, et al. Caffeic acid N-[3, 5-bis (trifluoromethyl) phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics. Scientific Reports, 2022, 12(1): 1-20. |