| Bioactivity | SR 33805 (analog) is an orally active Ca2+ channel blocker that selectively inhibits the proliferation of smooth muscle cells. SR 33805 (analog) reduces calcium uptake by blocking calcium channels, thereby inhibiting smooth muscle cell proliferation induced by serum, platelet-derived growth factor, and basic fibroblast growth factor. SR 33805 (analog) significantly reduces intimal thickening following endothelial injury in rabbits. SR 33805 (analog) shows promise for cardiovascular disease research, such as in early atherosclerosis[1]. |
| CAS | 121346-32-5 |
| Formula | C32H40N2O5S |
| Molar Mass | 564.74 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dol F, et al. Effect of SR 33805 on arterial smooth muscle cell proliferation and neointima formation following vascular injury. Eur J Pharmacol. 1995 Jul 4;280(2):135-42. |
SR33805 analog
CAS: 121346-32-5 F: C32H40N2O5S W: 564.74
SR 33805 (analog) is an orally active Ca2+ channel blocker that selectively inhibits the proliferation of smooth muscle
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