| Bioactivity | SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1[1]. | ||||||||||||
| Target | EC50: 800 nM (RORγt). | ||||||||||||
| Invitro | SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production[1]. | ||||||||||||
| Name | SR0987 | ||||||||||||
| CAS | 303126-97-8 | ||||||||||||
| Formula | C16H10ClF6NO2 | ||||||||||||
| Molar Mass | 397.70 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Chang MR, et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8. |