| Bioactivity | SQ-3 is a quinoline analogue, displays moderate selectivity for α-syn aggregates (Ki=39.3 nM) over β-amyloid (Aβ) aggregates (Ki=230 nM). [18F]SQ3 has basic properties as a lead compound for the development of a useful α-syn imaging probe[1]. |
| In Vivo | SQ-3 ([18F]SQ3) exhibits high uptake (2.08% ID/g at 2 min after intravenous injection) into a normal mouse brain[1]. |
| Name | SQ-3 |
| Formula | C21H21FN2O |
| Molar Mass | 336.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nakagawa K, et al. Structure-Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as α-Synuclein Imaging Probes. ACS Med Chem Lett. 2022 Sep 26;13(10):1598-1605. |