| Bioactivity | SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment[1]. |
| CAS | 1621616-13-4 |
| Sequence | Ac-Cys-Val-Asp-Ile-Asn-Asn-Asn-Cys-NH2 (Disulfide bridge: Cys1-Cys8) |
| Shortening | Ac-CVDINNNC-NH2 (Disulfide bridge: Cys1-Cys8) |
| Formula | C35H56N12O14S2 |
| Molar Mass | 933.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yap BK, et al., A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent. J Med Chem. 2014 Aug 28;57(16):7006-15. |
SPSB2-iNOS inhibitory cyclic peptide-1
CAS: 1621616-13-4 F: C35H56N12O14S2 W: 933.02
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2)
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