SPSB2-iNOS inhibitory cyclic peptide-1 TFA_product_DataBase

Bioactivity	SPSB2-iNOS inhibitory cyclic peptide-1 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-1(HY-P10383). SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment[1].
Sequence	Ac-Cys-Val-Asp-Ile-Asn-Asn-Asn-Cys-NH2 (Disulfide bridge: Cys1-Cys8)
Shortening	Ac-CVDINNNC-NH2 (Disulfide bridge: Cys1-Cys8)
Formula	C35H56N12O14S2.xC2HF3O2
Molar Mass	933.02 (free acid)
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yap BK, et al., A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent. J Med Chem. 2014 Aug 28;57(16):7006-15.

PeptideDB