| Bioactivity | SPR41 is a potent SARS-CoV-2 main protease inhibitor with Ki values of 0.184, 0.252, 14.4 µM for SARS-CoV-2 Mpro, hCatL, hCatB, respectively. SPR41 shows antiviral and cytotoxicity[1]. |
| Target | Ki: 0.184 µM (SARS-CoV-2 Mpro); 0.252 µM (hCatL); 14.4 µM (hCatB) |
| Invitro | SPR41 (0-100 µM; 1 h) 表现出抗病毒和细胞毒性，对 SARS-CoV-2 感染的Huh-7-ACE2 细胞的 EC50 为 1.8 µM，对未感染的 Huh-7-ACE2 细胞的 CC50 值为 14.5 µM[1]。 |
| Name | SPR41 |
| Formula | C27H37N3O5 |
| Molar Mass | 483.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Previti S, et al. Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors. Eur J Med Chem. 2022 Dec 15;247:115021. |