| Bioactivity | SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM (patent CN 107141287, SPOP-B-88)[1]. | ||||||||||||
| Target | SPOP | ||||||||||||
| Invitro | SPOP-IN-6b shows IC50s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2, and 786-0 cells[1].SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content[1]. | ||||||||||||
| In Vivo | SPOP-IN-6b (40-80 mg/kg; i.p.; daily; for 25 days) can slow down the growth of tumour by suppressing SPOP[1]. Animal Model: | ||||||||||||
| Name | SPOP-IN-6b | ||||||||||||
| CAS | 2136270-20-5 | ||||||||||||
| Formula | C28H32N6O3 | ||||||||||||
| Molar Mass | 500.59 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Guangcai Y, et al. The pyrido-pyrimidines of 2- imines -5- ketone group -2,5- dihydros -1-H- two. CN107141287A. |