| Bioactivity | SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM[1]. |
| Invitro | SPOP-IN-6b shows IC50s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2 and 786-0 cells[1].SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content[1]. |
| In Vivo | SPOP-IN-6b (40-80 mg/kg; intraperitoneal injection; daily; for 25 days; nude mice) can slow down the growth of tumour by suppressing SPOP[1]. |
| Name | SPOP-IN-6b hydrochloride |
| CAS | 2136270-68-1 |
| Formula | C28H33ClN6O3 |
| Molar Mass | 537.05 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guangcai Y, et al. The pyrido-pyrimidines of 2- imines -5- ketone group -2,5- dihydros -1-H- two. CN107141287A. |
SPOP-IN-6b hydrochloride
CAS: 2136270-68-1 F: C28H33ClN6O3 W: 537.05
SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM.
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This product is for research use only, not for human use. We do not sell to patients.