| Bioactivity | SPI-001 is a PPM1D-specific inhibitor (IC50=0.48 μM) with anticancer activity. SPI-001 inhibits PPM1D phosphatase activity and increases p53 phosphorylation in PPM1D-overexpressing human breast cancer cells. In addition, SPI-001 inhibits cell proliferation by inducing apoptosis[1]. |
| CAS | 1220996-46-2 |
| Formula | C30H60O4Si2 |
| Molar Mass | 540.97 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yagi, et al. "A small molecule inhibitor of p53-inducible protein phosphatase PPM1D." Bioorganic & medicinal chemistry letters 22.1 (2012): 729-732. |