| Bioactivity | SPDZi1 is a potent and selective syntenin inhibitor that binds to PDZ1 and PDZ2 domains of syntenin. SPDZi1 binds to the syntenin PDZ tandem (STNPDZ) with a Kd of 3.6 μM. SPDZi1 suppresses glioblastoma and reduces the activation of NF-κB, a downstream effector of syntenin[1]. |
| Invitro | SPDZi1 (Z3322068027；20 μM；24 小时) 可抑制人类多形性胶质母细胞瘤 (GBM) 细胞增殖，同时降低 NF-κB 的活化[1]。 在胶质母细胞瘤类器官 (GBO) 中，SPDZi1 可有效抑制小 GBO 的生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SPDZi1 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Formula | C22H19N3O5 |
| Molar Mass | 405.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yunseok Heo, et al. Discovery of a potent inhibitor that suppresses glioblastoma by dual targeting of both syntenin PDZ domains. bioRxiv preprint. April 04, 2024. |