| Bioactivity | SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases[1][2]. |
| Invitro | SPC4061 reduces PCSK9 mRNA levels in treated cells[1]. |
| In Vivo | SPC4061 (20 mg/kg first s.c.; and 5 mg/kg at day 7-28, once weekly for 4 weeks) produces a significant reduction in serum PCSK9 protein levels in monkey models[1]. |
| Name | SPC4061 |
| CAS | 1018108-22-9 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lindholm MW, et al. PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates. Mol Ther. 2012 Feb;20(2):376-81. [2]. Li Chuan-Yuan, et al. PCSK9 inhibitor compositions and methods for the treatment of cancer associated with PCSK9 expression: World Intellectual Property Organization, WO2020005869 A2 2020-01-02. |