| Bioactivity | SPA107 (Hemiasterlin methyl ester) is a Hemiasterlin (HY-117371) analog. SPA107 inhibits the polymerization of tubulin, exhibits antimitotic activity (IC50 of 0.5 nM) and cytotoxicity in p53 mutated MCF-7 cell with IC50 of 0.5 nM[1]. |
| CAS | 179939-69-6 |
| Formula | C31H48N4O4 |
| Molar Mass | 540.74 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nieman JA, et al., Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues. J Nat Prod. 2003 Feb;66(2):183-99. |